Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544497 | 0.89 | DHFR (0.47) | DHFR | |
| SCHEMBL9765081 | 0.81 | DHFR (0.56) | DHFR | |
| SCHEMBL9765067 | 0.81 | DHFR (0.71) | DHFR | |
| SCHEMBL9541999 | 0.80 | DHFR (0.66) | DHFR | |
| SCHEMBL9544509 | 0.78 | DHFR (0.50) | DHFR | |
| SCHEMBL9544514 | 0.76 | DHFR (0.48) | DHFR | |
| SCHEMBL9544503 | 0.75 | DHFR (0.40) | DHFR | |
| SCHEMBL13508620 | 0.69 | HDAC8 (0.62) | — | |
| SCHEMBL9068396 | 0.68 | DHFR (0.60) | DHFR | |
| SCHEMBL20504348 | 0.67 | LOXL2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013102-A1 | DEAZAAMINOPTERINS | SOUTHERN RESEARCH INSTITUTE (US) | 1993-07-08 | — | — | WO | disclosed |
| US-5077404-A | Cyclized 5,10-dideazaaminopterin compounds | SRI INTERNATIONAL | 1991-12-31 | — | — | US | disclosed |