Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544156 | 0.77 | HTR2C (0.49) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9545377 | 0.76 | MEN1 (0.41) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9370953 | 0.75 | CYP2A6 (0.38) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL9376868 | 0.74 | HTR2B (0.40) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7378778 | 0.73 | KDM1A (0.41) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9545320 | 0.73 | PIK3CD (0.39) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9542979 | 0.73 | GRK5 (0.47) | HTR2CNPC1SMN1; SMN2MEN1TP53 | |
| SCHEMBL27469254 | 0.73 | HTR2B (0.40) | HTR2CMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9542983 | 0.73 | MAPT (0.44) | HTR2CMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL18962969 | 0.73 | MAPT (0.52) | HTR2CNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993018028-A1 | INDOLE DERIVATIVES AS 5HT1C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-09-16 | — | — | WO | claimed |
| WO-1993018028-A1 | INDOLE DERIVATIVES AS 5HT1C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-09-16 | — | — | WO | disclosed |