Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29514402 | 0.88 | KDM4E (0.46) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL16391417 | 0.82 | KDM4E (0.50) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL476765 | 0.81 | KDM4E (0.53) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL18640775 | 0.81 | TSHR (0.56) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL95926 | 0.81 | KDM4E (0.56) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL13557891 | 0.81 | KDM4E (0.56) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| Boric Acid SCHEMBL29765260 | 0.81 | KDM4E (0.49) | KDM4EPOLBTSHRTACR1ALDH1A1 | |
| SCHEMBL18561111 | 0.79 | ALDH1A1 (0.39) | KDM4EPOLBTACR1ALDH1A1MEN1 | |
| Tert-Butanol SCHEMBL27883617 | 0.78 | TSHR (0.71) | KDM4EPOLBTSHRALDH1A1CA1 | |
| SCHEMBL13888734 | 0.78 | KDM4E (0.46) | KDM4EPOLBTSHRTACR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5178778-A | — | — | None | — | — | JP | disclosed |
| US-20170298055-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170298055-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170298055-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
| WO-2016044445-A2 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044445-A2 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| JP-H05178778-A | TERTIARY ALCOHOL COMPOUND HAVING TRIFLUOROMETHYL GROUP AND ITS PRODUCTION | NIKKO KYODO CO LTD | 1993-07-20 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298055-A1 | sGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG2 | KDM4E 1724/4885POLB 4027/4885TSHR 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.