SCHEMBL9545294

SCHEMBL9545294

COC(=O)CCNC(=O)[C@@H]1Cc2ccccc2N1C(=O)[C@H](CCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 5/20 0.44
CCKAR P32238 3/20 0.44
CYP51A1 Q16850 1/20 0.44
PYGL P06737 1/20 0.44
MMP3 P08254 1/20 0.42
PTGER4 P35408 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9544831 0.93 CCKBR (0.47) CCKBRCCKARCYP51A1PYGLMMP3
SCHEMBL9545290 0.87 CCKAR (0.47) CCKBRCCKARCYP51A1PYGLMMP3
SCHEMBL9548135 0.87 CCKBR (0.47) CCKBRCCKARCYP51A1PYGLMMP3
SCHEMBL9543252 0.82 CXCR3 (0.51)
SCHEMBL9544385 0.80 CCKBR (0.49) CCKBRCCKARCYP51A1PYGL
SCHEMBL9542540 0.80 CCKBR (0.51) CCKBRCCKARCYP51A1PYGL
SCHEMBL9545032 0.80 CCKBR (0.51) CCKBRCCKARCYP51A1PYGL
SCHEMBL9542711 0.78 CCKBR (0.47) CCKBRCCKARCYP51A1PYGLMMP3
SCHEMBL9543489 0.77 CCKBR (0.48) CCKBRCCKARCYP51A1PYGLMMP3
SCHEMBL9544112 0.72 CYP51A1 (0.59) CCKBRCCKARCYP51A1PYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993020099-A2 CCK AND/OR GASTRIN RECEPTOR LIGANDS FERRING B.V. (NL) 1993-10-14 WO disclosed