Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 18/20 | 0.54 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8467505 | 0.98 | FDPS (0.56) | FDPSGGPS1PDE3ALMNAADRB3 | |
| Iodide SCHEMBL8467514 | 0.87 | FDPS (0.55) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL15452876 | 0.85 | FDPS (0.48) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL8778333 | 0.84 | FDPS (0.57) | FDPSGGPS1PDE3ALMNAADRB3 | |
| Hydrochloric Acid SCHEMBL16037116 | 0.84 | FDPS (0.60) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL15452839 | 0.81 | FDPS (0.62) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL16089353 | 0.81 | FDPS (0.62) | FDPSGGPS1PDE3ALMNAADRB3 | |
| Iodide SCHEMBL8468421 | 0.75 | FDPS (0.61) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL15452874 | 0.75 | FDPS (0.55) | FDPSGGPS1PDE3ALMNAADRB3 | |
| Hydrochloric Acid SCHEMBL8467436 | 0.75 | FDPS (0.61) | FDPSGGPS1PDE3AAGTR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993024494-A1 | QUATERNARY NITROGEN-CONTAINING PHOSPHONATE COMPOUNDS, FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | THE PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |