Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | LY6K | Q17RY6 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547241 | 0.77 | TOP2A (0.51) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300759 | 0.74 | TOP2B (0.53) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9299716 | 0.73 | POLB (0.43) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300528 | 0.73 | ELANE (0.48) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9547266 | 0.71 | KDM1A (0.44) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300653 | 0.71 | POLB (0.47) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300832 | 0.71 | TOP2A (0.47) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300635 | 0.70 | KDM4E (0.42) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300661 | 0.69 | TOP2A (0.47) | TOP2ATOP2BKMT2AMEN1GAA | |
| SCHEMBL9300901 | 0.69 | KDM4E (0.48) | TOP2ATOP2BKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993023049-A1 | 3-(9-ACRIDINYLAMINO)-5-HYDROXYMETHYLANILINE DERIVATIVES AS ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-11-25 | — | — | WO | claimed |