SCHEMBL9547382

SCHEMBL9547382

C[Si](C)(C[Si](C)(CCl)c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.32
LMNA P02545 1/20 0.32
CYP2A6 P11509 1/20 0.32
TAAR1 Q96RJ0 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HTT P42858 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9559622 0.91 TP53 (0.39) ALDH1A1HTTRAB9A
SCHEMBL10614995 0.85 LMNA (0.40) GSK3BLMNACYP2A6TAAR1ALDH1A1
SCHEMBL9559638 0.82 TAAR1 (0.31) TAAR1
SCHEMBL8983871 0.81 LMNA (0.40) GSK3BLMNACYP2A6TAAR1ALDH1A1
SCHEMBL9559554 0.75 NPC1 (0.38) ALDH1A1HTTRAB9A
SCHEMBL4734052 0.74 LMNA (0.38) LMNACYP2A6TAAR1ALDH1A1HTT
SCHEMBL10941811 0.73 SMN1; SMN2 (0.43) LMNAALDH1A1HTT
SCHEMBL9559633 0.73 MAP2K4 (0.36) RAB9A
SCHEMBL9559574 0.73 NPC1 (0.39) LMNAALDH1A1HTTRAB9A
SCHEMBL9559556 0.72 NQO1 (0.41) LMNAALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5202072-A None JP disclosed
JP-H05202072-A (1H-1,2,4-TRIAZOLYL)DISILAALKANE AND ITS PREPARATION KOREA ADVANCED INST OF SCI TECHNOL 1993-08-10 JP disclosed
US-5235061-A 2,4-disilaalkanes; agriculture KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1993-08-10 US disclosed