SCHEMBL4734052

SCHEMBL4734052

C[Si](C)(CI)c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.38
CYP2A6 P11509 1/20 0.38
NOTUM Q6P988 4/20 0.32
IDO1 P14902 2/20 0.32
CYP1A2 P05177 1/20 0.32
POLB P06746 1/20 0.32
SLC6A2 P23975 2/20 0.31
SLC6A3 Q01959 2/20 0.31
TAAR1 Q96RJ0 1/20 0.31
HTR2A P28223 1/20 0.31
SLC6A4 P31645 1/20 0.31
HRH1 P35367 1/20 0.31
HTR2B P41595 1/20 0.31
CHRNA4 P43681 1/20 0.31
AHR P35869 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
TP53 P04637 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30504685 0.78 LMNA (0.40) LMNACYP2A6IDO1CYP1A2SLC6A2
SCHEMBL8983871 0.78 LMNA (0.40) LMNACYP2A6NOTUMIDO1SLC6A2
SCHEMBL2008775 0.76 TAAR1 (0.39) LMNACYP2A6NOTUMIDO1SLC6A2
SCHEMBL7813105 0.75 MAPT (0.44) LMNAALDH1A1HPGDTP53
SCHEMBL9559554 0.74 NPC1 (0.38) ALDH1A1TP53HTT
SCHEMBL9559741 0.74 NPC1 (0.38) LMNAALDH1A1TP53HTT
SCHEMBL9547382 0.74 GSK3B (0.32) LMNACYP2A6TAAR1ALDH1A1HTT
SCHEMBL9559693 0.74 LMNA (0.32) LMNACYP2A6
SCHEMBL2003777 0.73 TAAR1 (0.41) LMNACYP2A6NOTUMCYP1A2SLC6A2
SCHEMBL7523490 0.73 NR1H2 (0.42) IDO1TAAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008063134-A1 METHOD OF PRODUCING A PATTERN OF DISCRIMINATIVE WETTABILITY AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2008-05-29 WO claimed