Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 18/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20851704 | 0.83 | ESR1 (0.55) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL10947056 | 0.83 | CYP19A1 (0.43) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL10947066 | 0.83 | CYP19A1 (0.43) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL6689499 | 0.83 | ESR1 (0.55) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL20851686 | 0.83 | ESR1 (0.55) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL9547847 | 0.82 | CYP19A1 (0.64) | ESR1PGRARSHBGOPRM1 | |
| SCHEMBL9547834 | 0.80 | ESR1 (0.45) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL7861153 | 0.79 | CYP19A1 (0.66) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL8424668 | 0.76 | PGR (0.50) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL7862313 | 0.75 | CYP19A1 (0.46) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210678-B1 | NOVEL LL-METHYLENE-OESTR-15-ENES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1989-09-20 | — | — | EP | claimed |
| EP-0210678-A1 | Novel ll-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions | AKZO N.V. (NL) | 1987-02-04 | — | — | EP | claimed |
| US-5236913-A | Powerful gestagenic properties and only slight androgenic side effects | AKZO N.V. (NL) | 1993-08-17 | — | — | US | disclosed |
| EP-0210678-B1 | NOVEL LL-METHYLENE-OESTR-15-ENES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1989-09-20 | — | — | EP | disclosed |
| EP-0210678-A1 | Novel ll-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions | AKZO N.V. (NL) | 1987-02-04 | — | — | EP | disclosed |