Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.46 |
| ▸ | GNG2 | P59768 | 1/20 | 0.40 |
| ▸ | GNB1 | P62873 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11808909 | 0.86 | GSK3B (0.52) | GSK3BTAS1R3TAS1R1PTPN1GNG2 | |
| SCHEMBL10651588 | 0.83 | PTPN1 (0.48) | GSK3BPTPN1GNG2GNB1MEN1 | |
| SCHEMBL30187429 | 0.80 | GSK3B (0.61) | GSK3BPTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL1726590 | 0.80 | GSK3B (0.61) | GSK3BPTPN1MEN1KMT2AL3MBTL1 | |
| SCHEMBL10807506 | 0.79 | GSK3B (0.51) | GSK3BPTPN1MEN1KMT2ATHRA | |
| SCHEMBL701970 | 0.78 | TAS1R3 (0.50) | TAS1R3TAS1R1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9548004 | 0.78 | TAS1R3 (0.50) | TAS1R3TAS1R1KMT2AL3MBTL1 | |
| SCHEMBL6738215 | 0.78 | GSK3B (0.50) | GSK3BPTPN1 | |
| SCHEMBL29966893 | 0.78 | PTPN1 (0.50) | GSK3BPTPN1 | |
| SCHEMBL6113125 | 0.78 | PTPN1 (0.50) | GSK3BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198587-A | Adrenergic Blocking Agents, Hypotensive Agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5063246-A | Hypotensive | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| US-4880841-A | ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |