SCHEMBL9548749

SCHEMBL9548749

C[SiH](C)[C@@]1(n2cnc3c(N)nc(N)nc32)C[C@H](OC(C)(C)C)[C@@H](C=O)O1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.33
CCNB1 P14635 2/20 0.33
CCNE1 P24864 2/20 0.33
CDK2 P24941 2/20 0.33
HINT1 P49773 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
NT5E P21589 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9548795 0.81 ADORA3 (0.33) ADORA3
SCHEMBL9548835 0.72 ADORA2A (0.44) ADORA3ADORA2AADORA1
SCHEMBL1675421 0.72 ADORA3 (0.33) ADORA3ADORA2AADORA1
SCHEMBL2293030 0.71 RXFP1 (0.42)
SCHEMBL9548623 0.70 ADORA3 (0.40) HINT1ADORA3
SCHEMBL11903873 0.70 ADORA2A (0.33) ADORA3ADORA2AADORA1
SCHEMBL9227355 0.70 PI4KA (0.37) ADORA3ADORA2AADORA1NT5E
SCHEMBL25388932 0.68 ADORA3 (0.47) CDK1ADORA3ADORA2AADORA1NT5E
SCHEMBL9548707 0.65 ADORA3 (0.41) ADORA3ADORA2A
SCHEMBL9548872 0.64 PNP (0.43) HINT1NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5192749-A Viricide, AIDS SYNTEX (U.S.A.) INC. (US) 1993-03-09 US disclosed