Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 12/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.39 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27640857 | 0.90 | MTNR1A (0.46) | MTNR1BMTNR1AAKR1B1TDP1DUSP3 | |
| SCHEMBL21626216 | 0.85 | MTNR1B (0.47) | MTNR1BMTNR1ASLC9A1SLC9A5SLC9A2 | |
| SCHEMBL21224523 | 0.80 | MTNR1A (0.50) | MTNR1BMTNR1A | |
| SCHEMBL8405200 | 0.79 | MTNR1B (0.52) | MTNR1BMTNR1ASLC9A1SLC9A5SLC9A2 | |
| SCHEMBL6192119 | 0.79 | MTNR1B (0.46) | MTNR1BMTNR1ASLC9A1SLC9A5SLC9A2 | |
| SCHEMBL31285847 | 0.79 | AKR1B1 (0.42) | AKR1B1TDP1DUSP3PTPN5PTPN11 | |
| SCHEMBL3639598 | 0.78 | MTNR1A (0.59) | MTNR1AAKR1B1TDP1 | |
| SCHEMBL6948957 | 0.76 | MTNR1A (0.48) | MTNR1BMTNR1ASLC9A1SLC9A5SLC9A2 | |
| SCHEMBL6950092 | 0.76 | MTNR1A (0.44) | MTNR1BMTNR1ASLC9A1 | |
| SCHEMBL21409034 | 0.75 | MTNR1B (0.43) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012754-A2 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1993-07-08 | — | — | WO | claimed |
| WO-1993012754-A2 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1993-07-08 | — | — | WO | disclosed |