Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550016 | 0.78 | MEN1 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12105263 | 0.72 | CHRNB2 (0.50) | CHRNB2CHRNA4DRD2DRD3CHRNB4 | |
| Bromide SCHEMBL1206747 | 0.71 | CHRNB2 (0.49) | CHRNB2CHRNA4DRD2DRD3CHRNB4 | |
| SCHEMBL1396406 | 0.69 | CHRNB2 (0.39) | CHRNB2CHRNA4ESR1ESR2DRD2 | |
| SCHEMBL19956276 | 0.69 | PLG (0.40) | CHRNB2CHRNA4ESR2DRD2DRD3 | |
| SCHEMBL11801980 | 0.67 | CHRNB2 (0.37) | CHRNB2CHRNA4ESR1ESR2DYRK1A | |
| SCHEMBL16758746 | 0.66 | CHRNB2 (0.36) | CHRNB2CHRNA4 | |
| SCHEMBL2903184 | 0.66 | CHRNB2 (0.50) | CHRNB2CHRNA4ESR1ESR2DRD2 | |
| SCHEMBL6995541 | 0.64 | CHRNB2 (0.68) | CHRNB2CHRNA4ESR1ESR2CHRNB4 | |
| SCHEMBL8313932 | 0.62 | QDPR (0.55) | CHRNB2CHRNA4ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | claimed |
| US-5264575-A | Reacting 1,3-benzodiazocine-8-ol derivative with lutidine/2,6-/, triisoproylsilyltrifluoro methane, formed intermediate reacted with lithium chloride, tetrabutylammonium fluoride and isocyanate | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5097033-A | Aminoethyl quinoline 2-ones, intermediates for analgesic, and cholinergic agents for memory disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | disclosed |