Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.68 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406668 | 0.81 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17699117 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4DYRK1AESR2ESR1 | |
| Hydrochloric Acid SCHEMBL4416383 | 0.79 | CHRNB2 (0.96) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7459638 | 0.76 | CHRNB2 (0.50) | CHRNB2CHRNA4DYRK1AESR2ESR1 | |
| SCHEMBL12105263 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4DYRK1ACHRNB4CHRNA3 | |
| SCHEMBL19249421 | 0.74 | TYR (0.48) | CHRNB2CHRNA4DYRK1AESR2 | |
| Bromide SCHEMBL1206747 | 0.74 | CHRNB2 (0.49) | CHRNB2CHRNA4DYRK1ACHRNB4CHRNA3 | |
| SCHEMBL8842402 | 0.73 | SIGMAR1 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1819320 | 0.73 | KDM1A (0.41) | CHRNB2CHRNA4RARGRARBCHRNB4 | |
| SCHEMBL20627668 | 0.73 | KDM1A (0.41) | CHRNB2CHRNA4RARGRARBCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015437-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |
| EP-1015437-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999012915-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | disclosed |