Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.43 |
| ▸ | NQO2 | P16083 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9549963 | 0.85 | MTNR1A (0.44) | LMNAMTNR1AMTNR1BNQO2 | |
| SCHEMBL9549917 | 0.85 | LMNA (0.48) | LMNAMTNR1AMTNR1BNQO2MEN1 | |
| SCHEMBL9549943 | 0.82 | MTNR1A (0.42) | LMNAMTNR1AMTNR1BNQO2MEN1 | |
| SCHEMBL9550084 | 0.80 | LMNA (0.48) | LMNANQO2MEN1TSHRKMT2A | |
| SCHEMBL9549959 | 0.79 | LMNA (0.47) | LMNAMTNR1ANQO2HTR6ALDH1A1 | |
| SCHEMBL6073564 | 0.76 | LMNA (0.55) | LMNAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL14493795 | 0.68 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL29249783 | 0.68 | MEN1 (0.54) | LMNAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL31092698 | 0.68 | MEN1 (0.54) | LMNAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL31092759 | 0.68 | ALDH1A1 (0.53) | LMNAMEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5264575-A | Reacting 1,3-benzodiazocine-8-ol derivative with lutidine/2,6-/, triisoproylsilyltrifluoro methane, formed intermediate reacted with lithium chloride, tetrabutylammonium fluoride and isocyanate | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5097033-A | Aminoethyl quinoline 2-ones, intermediates for analgesic, and cholinergic agents for memory disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0335292-A2 | 2,6-Methano-1,3-benzodiazocines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-10-04 | — | — | EP | disclosed |