Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550709 | 0.84 | HPN (0.50) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL8309788 | 0.84 | VCAM1 (0.55) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9497169 | 0.84 | HPN (0.50) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9550813 | 0.81 | HPN (0.41) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9328168 | 0.81 | PTGS1 (0.61) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL646924 | 0.81 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9550714 | 0.80 | HPN (0.46) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9154935 | 0.80 | ALOX15 (0.57) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL8336942 | 0.79 | GAA (0.62) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9550716 | 0.78 | HPN (0.47) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | claimed |
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |