Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813051 | 0.84 | PTPN1 (0.44) | BACE1PTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL9550710 | 0.84 | ALDH1A1 (0.49) | PTPN1PTPN2PTPN6ALDH1A1CYP1A2 | |
| SCHEMBL9550722 | 0.82 | PTPN1 (0.42) | BACE1PTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL9550715 | 0.81 | PTPN1 (0.41) | BACE1PTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL19274345 | 0.81 | LTB4R (0.45) | ATMALDH1A1LMNAAPPCYP1A2 | |
| SCHEMBL28897181 | 0.80 | CYP1A2 (0.59) | ATMALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL9550711 | 0.79 | ALDH1A1 (0.47) | BACE1PTPN1PTPN2PTPN6ALDH1A1 | |
| SCHEMBL21016682 | 0.77 | LTB4R (0.43) | ATMPTPN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9510615 | 0.77 | SMN1; SMN2 (0.53) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL9838242 | 0.76 | TDP1 (0.44) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0339688-B1 | HYDROXYPHENYLTHIOALKYLKETONES | G.D. Searle & Co. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0339688-A1 | Hydroxyphenylthioalkylketones | G.D. Searle & Co. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |