Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 5/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL29200865 | 0.93 | KDM4E (0.55) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL3624598 | 0.90 | MEN1 (0.42) | KDM4EMAPTKMT2AMEN1LMNA | |
| D-Tryptophan SCHEMBL14691185 | 0.89 | KDM4E (0.57) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL3626370 | 0.88 | MEN1 (0.41) | KDM4EMAPTKMT2AMEN1LMNA | |
| D-Tryptophan SCHEMBL14691096 | 0.87 | KDM4E (0.53) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL8936380 | 0.85 | KDM4E (0.61) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28481662 | 0.85 | KDM4E (0.64) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28689794 | 0.84 | KDM4E (0.60) | KDM4EMAPTKMT2AMEN1LMNA | |
| Dl-Tryptophan SCHEMBL29013076 | 0.84 | KMT2A (0.63) | KDM4EMAPTKMT2AMEN1LMNA | |
| Tryptophan SCHEMBL14691207 | 0.84 | KDM4E (0.63) | KDM4EMAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528891-A1 | METHOD FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY | ALKERMES, INC. (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1991016355-A1 | METHOD FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY | ALKERMES, INC. (US) | 1991-10-31 | — | — | WO | disclosed |