Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 2/20 | 0.39 |
| ▸ | GRPR | P30550 | 7/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL3624598 | 0.98 | MEN1 (0.42) | MEN1KMT2AKDM4ELMNAMPO | |
| Tryptophan SCHEMBL9551469 | 0.88 | KDM4E (0.53) | MEN1KMT2AKDM4ELMNAMPO | |
| Histidine SCHEMBL9646532 | 0.87 | — | — | |
| Dl-Tryptophan SCHEMBL20857030 | 0.84 | KMT2A (0.57) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27789301 | 0.83 | CTSC (0.41) | MEN1KMT2AKDM4ELMNAMPO | |
| Histidine SCHEMBL9120374 | 0.83 | SLC7A5 (0.30) | — | |
| Dl-Tryptophan SCHEMBL28831650 | 0.83 | CTSC (0.41) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27649388 | 0.82 | MEN1 (0.44) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL27169619 | 0.82 | KMT2A (0.54) | MEN1KMT2AKDM4ELMNAMPO | |
| Dl-Tryptophan SCHEMBL28689794 | 0.82 | KDM4E (0.60) | MEN1KMT2AKDM4ELMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100015058-A1 | RADIOLABELED BBN-RGD HETERODIMERS FOR CANCER TARGETING | STANFORD UNIVERSITY (US) | 2010-01-21 | — | — | US | claimed |
| US-20100015058-A1 | RADIOLABELED BBN-RGD HETERODIMERS FOR CANCER TARGETING | STANFORD UNIVERSITY (US) | 2010-01-21 | — | — | US | disclosed |