Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 12/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9554834 | 1.00 | REN (0.32) | RENBACE1BACE2CTSD | |
| SCHEMBL9554656 | 0.88 | REN (0.45) | RENBACE1BACE2CTSD | |
| SCHEMBL9554642 | 0.88 | REN (0.45) | RENBACE1BACE2CTSD | |
| SCHEMBL9554637 | 0.88 | CA2 (0.41) | RENBACE1CTSD | |
| SCHEMBL9555200 | 0.86 | REN (0.41) | RENCTSD | |
| SCHEMBL9554322 | 0.86 | REN (0.41) | RENCTSD | |
| SCHEMBL9554457 | 0.86 | REN (0.41) | RENCTSD | |
| SCHEMBL10509223 | 0.82 | REN (0.31) | REN | |
| SCHEMBL10511960 | 0.82 | REN (0.31) | REN | |
| SCHEMBL9554946 | 0.81 | REN (0.48) | RENBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0310918-A2 | Peptide-like amino-acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-12 | — | — | EP | disclosed |