Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30875172 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5239507 | 0.87 | ALDH1A1 (0.63) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL29429164 | 0.87 | POLB (0.74) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9587727 | 0.87 | POLB (0.74) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22478566 | 0.85 | ALDH1A1 (0.67) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| Mecarbinate SCHEMBL2109102 | 0.83 | LMNA (0.72) | SMN1; SMN2POLBALDH1A1HSD17B10HPGD | |
| Mecarbinate SCHEMBL29380431 | 0.83 | LMNA (0.72) | SMN1; SMN2POLBALDH1A1HSD17B10HPGD | |
| SCHEMBL3384928 | 0.83 | KDM4E (0.71) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9198378 | 0.83 | HTT (0.76) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL21954348 | 0.82 | ALDH1A1 (0.63) | SMN1; SMN2POLBALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3496763-B1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH INC (US) | 2026-04-01 | — | — | EP | disclosed |
| CN-109689111-B | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | 基因泰克公司 | 2024-04-05 | — | — | CN | disclosed |
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | GENENTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | GENENTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| US-20220185821-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 4 ANTAGONISTS IN THE TREATMENT OF ANEMIA | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2022-06-16 | — | — | US | disclosed |
| CN-113613650-A | Muscarinic acetylcholine receptor subtype 4 antagonists for the treatment of anemia | 冷泉港实验室 | 2021-11-05 | — | — | CN | disclosed |
| US-20200085965-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| EP-3496763-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | Genentech, Inc. (US) | 2019-06-19 | — | — | EP | disclosed |
| US-20190175749-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| US-20190175749-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| WO-2018031662-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2018-02-15 | — | — | WO | disclosed |
| WO-2018031662-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2018-02-15 | — | — | WO | disclosed |
| US-5189041-A | Gastrointestinal and nervous system disorders, cardiovascular disorders, analgesics | SYNTEX (U.S.A.) INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0485962-A2 | New tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1992-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190175749-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | NQO1, GSTP1, CYBB | SMN1; SMN2 4344/4885POLB 1709/4885ALDH1A1 304/4885 |
| US-20220185821-A1 | MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 4 ANTAGONISTS IN THE TREATMENT OF ANEMIA | CHRNE, CHRNG, CHRM4 | SMN1; SMN2 3630/4885POLB 2985/4885ALDH1A1 3160/4885 |
| US-20200085965-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | NQO1, GSTP1, CYBB | SMN1; SMN2 4344/4885POLB 1709/4885ALDH1A1 304/4885 |
| US-11576979-B2 | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof | NQO1, GSTP1, CYBB | SMN1; SMN2 4344/4885POLB 1709/4885ALDH1A1 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.