Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20544704 | 0.76 | BTK (0.44) | BTKNPSR1RXFP1GRM5CSNK1A1 | |
| SCHEMBL28008449 | 0.73 | BTK (0.50) | BTKNPSR1RXFP1GRM5CSNK1A1 | |
| SCHEMBL530054 | 0.73 | BCAT2 (0.61) | BTKGRM5CSNK1A1TYRO3DYRK1B | |
| SCHEMBL2012719 | 0.71 | GRM5 (0.53) | BTKNPSR1RXFP1GRM5CSNK1A1 | |
| SCHEMBL1068321 | 0.69 | KDM4E (0.52) | TGFBR1 | |
| SCHEMBL27911586 | 0.69 | BCAT2 (0.55) | DHODHIKBKBMKNK1MKNK2BCAT2 | |
| SCHEMBL18765294 | 0.68 | NPSR1 (0.48) | BTKNPSR1RXFP1GRM5PARP1 | |
| SCHEMBL31395013 | 0.68 | NPSR1 (0.48) | BTKNPSR1RXFP1GRM5PARP1 | |
| SCHEMBL16826519 | 0.68 | MKNK1 (0.45) | NPSR1CSNK1A1TYRO3DYRK1BPARP1 | |
| SCHEMBL3404744 | 0.68 | KDM4E (0.50) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |