Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580589 | 0.84 | KDM4E (0.62) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2856220 | 0.82 | GAA (0.61) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1919434 | 0.81 | MEN1 (0.73) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8362169 | 0.81 | KDM4E (0.58) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5887976 | 0.80 | KDM4E (0.60) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5714681 | 0.79 | ALDH1A1 (0.70) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6663539 | 0.78 | — | — | |
| SCHEMBL10498542 | 0.78 | LMNA (0.70) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL7645352 | 0.78 | ALDH1A1 (0.57) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14973024 | 0.77 | KDM4E (0.60) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0371390-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |