Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.42 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558886 | 0.97 | HTR2A (0.42) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL7328468 | 0.72 | MAPT (0.54) | HPGDPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28800723 | 0.71 | MAPT (0.52) | HTR2AHPGDPOLBNPC1RAB9A | |
| SCHEMBL8094738 | 0.69 | GABRA2 (0.61) | — | |
| SCHEMBL1252469 | 0.69 | PARP1 (0.66) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL11407410 | 0.68 | PARP1 (0.64) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL13982464 | 0.66 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EALDH1A1TP53MAPT | |
| SCHEMBL4715817 | 0.66 | MAPT (0.41) | HPGDPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9558689 | 0.66 | HTR2A (0.47) | HTR2AHTR2CHTR2BHPGDPOLB | |
| SCHEMBL6329236 | 0.66 | KDM4E (0.76) | HPGDNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185338-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| EP-0484988-A1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-05-13 | — | — | EP | disclosed |
| US-5041443-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0384228-A1 | Medicament for treating cerebral insufficiency diseases containing 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-08-29 | — | — | EP | disclosed |