Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28800723 | 0.98 | MAPT (0.52) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL7323294 | 0.85 | ALDH1A1 (0.62) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL15572127 | 0.82 | POLB (0.49) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL15572722 | 0.74 | ALDH1A1 (0.50) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL9558654 | 0.72 | HTR2A (0.42) | MAPTALDH1A1POLBMAPK1L3MBTL1 | |
| SCHEMBL22570509 | 0.70 | ALDH1A1 (0.47) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL9558886 | 0.69 | HTR2A (0.42) | MAPTALDH1A1POLBMAPK1L3MBTL1 | |
| SCHEMBL8127178 | 0.68 | ALDH1A1 (0.46) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL21186930 | 0.68 | ALDH1A1 (0.46) | MAPTALDH1A1POLBALOX15MAPK1 | |
| SCHEMBL6989278 | 0.67 | PTGS1 (0.52) | MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-B1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1994-06-29 | — | — | EP | disclosed |