Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.47 |
| ▸ | HTR2C | P28335 | 9/20 | 0.47 |
| ▸ | HTR2B | P41595 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558713 | 0.98 | HTR2A (0.46) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL9558730 | 0.97 | KDM4E (0.48) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL4134361 | 0.80 | ALDH1A1 (0.52) | KDM4ENPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL183610 | 0.77 | HTR2A (0.75) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL25260102 | 0.77 | HRH2 (0.45) | HTR2AHTR2CHTR2BKDM4EALDH1A1 | |
| SCHEMBL9558720 | 0.77 | HRH2 (0.52) | HTR2AHTR2CHTR2BKDM4EALDH1A1 | |
| SCHEMBL716608 | 0.75 | KMT2A (0.52) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL24698706 | 0.75 | HRH2 (0.40) | KDM4EHPGDRAB9AALDH1A1TP53 | |
| SCHEMBL7500873 | 0.74 | KDM4E (0.45) | HTR2AHTR2CHTR2BKDM4ENPC1 | |
| SCHEMBL7332801 | 0.73 | DRD2 (0.52) | HTR2AKDM4ENPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185338-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| US-5041443-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0384228-A1 | Medicament for treating cerebral insufficiency diseases containing 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-08-29 | — | — | EP | disclosed |