Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | BID | P55957 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14465961 | 0.90 | LMNA (0.52) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL29350114 | 0.84 | LMNA (0.50) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL4623589 | 0.84 | LMNA (0.50) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL7026110 | 0.81 | ALDH1A1 (0.36) | THRBTDP1ALDH1A1LIPGMGLL | |
| SCHEMBL7031317 | 0.81 | ALDH1A1 (0.36) | THRBTDP1ALDH1A1LIPGMGLL | |
| SCHEMBL574810 | 0.81 | LIPG (0.58) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL9859793 | 0.81 | LIPG (0.58) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL28410253 | 0.81 | LIPG (0.58) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL20594223 | 0.81 | LIPG (0.58) | THRBLMNAKMT2AMEN1BLM | |
| SCHEMBL6679819 | 0.81 | LIPG (0.58) | THRBLMNAKMT2AMEN1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025564-C | Process for the preparation of phenyl epoxy hydroxy acid esters | SMITHKLINE BECKMAN CORP (US) | 1994-08-03 | — | — | CN | disclosed |
| EP-0358240-B1 | INTERMEDIATES FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |
| US-5034537-A | Alpha-methyl-4-halobenzenemethanamine salts of acids for cardiovascular disorders, respiratory system disorders and antiallergens | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4939279-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0202759-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-20 | — | — | EP | disclosed |
| CN-1008091-B | Process for preparing leukotriene antagonists | SMITHKLINE BECKMAN CORP (US) | 1990-05-23 | — | — | CN | disclosed |
| CN-1040586-A | Process for preparing leukotriene antagonists | SMITHKLINE BECKMAN CORP (US) | 1990-03-21 | — | — | CN | disclosed |
| EP-0358240-A2 | Intermediates for the preparation of leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874792-A | RESPIRATORY SYSTEM DISORDERS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4820719-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIISCHEMIC AND HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| CN-86102482-A | Process for preparing leukotriene antagonists | — | 1987-02-04 | — | — | CN | disclosed |
| EP-0202759-A2 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1986-11-26 | — | — | EP | disclosed |