SCHEMBL9561235

SCHEMBL9561235

CCOc1ccc(C(F)(COCc2c(F)c(F)c(C)c(F)c2F)C(F)(F)F)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.36
MAPT P10636 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
LMNA P02545 2/20 0.35
ATM Q13315 1/20 0.35
MAOB P27338 2/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
LTA4H P09960 2/20 0.33
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
NPY1R P25929 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
KIF11 P52732 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9560504 0.85 NQO1 (0.34) NQO1MAPTL3MBTL1LMNAATM
SCHEMBL9561180 0.85 NQO1 (0.34) NQO1MAPTL3MBTL1LMNAATM
SCHEMBL9560441 0.74 NQO1 (0.36) NQO1MAPTL3MBTL1LMNAATM
SCHEMBL9560404 0.73 CD274 (0.43)
SCHEMBL27691533 0.71 LTA4H (0.40) MAPTL3MBTL1LMNAATMMAOB
SCHEMBL9560443 0.70 LTA4H (0.48) MAPTL3MBTL1LMNAATMLTA4H
SCHEMBL9560672 0.68 LTA4H (0.42) MAPTL3MBTL1LMNAATMLTA4H
SCHEMBL1784131 0.66 MEN1 (0.31) TDP1MEN1KMT2A
SCHEMBL8237725 0.65 NQO1 (0.64) NQO1MAPTL3MBTL1LMNAATM
SCHEMBL18417195 0.64 NQO1 (0.56) NQO1MAPTL3MBTL1LMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
CN-1019191-B INSECTICIDAL ETHERS ICI PLC (GB) 1992-11-25 CN disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed
CN-86105891-A Desinsection ether 1987-02-25 CN disclosed