SCHEMBL9560504

SCHEMBL9560504

CCOc1ccc(C(Cl)(COCc2c(F)c(F)c(C)c(F)c2F)C(F)(F)F)cc1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.34
MAPT P10636 2/20 0.34
LMNA P02545 1/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MAOB P27338 2/20 0.32
CYP1A1 P04798 1/20 0.32
CYP1B1 Q16678 1/20 0.32
LTA4H P09960 1/20 0.31
TSHR P16473 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
NPY1R P25929 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9561235 0.85 NQO1 (0.36) NQO1MAPTLMNAATML3MBTL1
SCHEMBL9560876 0.74 CD274 (0.41)
SCHEMBL9560441 0.72 NQO1 (0.36) NQO1MAPTLMNAATML3MBTL1
SCHEMBL9560836 0.71 MAPT (0.41) MAPTLMNAATML3MBTL1MAOB
SCHEMBL9560713 0.71 LTA4H (0.46) MAPTLMNAATML3MBTL1LTA4H
SCHEMBL9560321 0.71 MAPT (0.40) MAPTLMNAATML3MBTL1LTA4H
SCHEMBL9560857 0.71 SLC5A2 (0.39) MAPTLMNAMAOBALDH1A1GAA
SCHEMBL9560391 0.70 MAPT (0.39) MAPTLMNAATML3MBTL1LTA4H
SCHEMBL9560848 0.70 ALDH1A1 (0.42) MAPTLMNAATML3MBTL1MAOB
SCHEMBL9560684 0.69 LTA4H (0.40) MAPTLMNAATML3MBTL1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed