Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.49 |
| ▸ | PPARA | Q07869 | 9/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823980 | 0.80 | PPARG (0.35) | PPARGPPARAALDH1A1HTTCYP3A4 | |
| SCHEMBL7087893 | 0.79 | PPARG (0.57) | PPARGPPARAADORA3ELANEPPARD | |
| SCHEMBL1960387 | 0.78 | PPARG (0.62) | PPARGPPARAADORA3ELANEMEN1 | |
| SCHEMBL2517199 | 0.76 | PPARG (0.54) | PPARGPPARAADORA3ELANEALDH1A1 | |
| SCHEMBL3975913 | 0.76 | PPARG (0.54) | PPARGPPARAADORA3ELANEPPARD | |
| SCHEMBL3465228 | 0.76 | PPARG (0.58) | PPARGPPARAADORA3ELANEPPARD | |
| SCHEMBL10408167 | 0.75 | LMNA (0.37) | ALDH1A1HTTMEN1MAPTKMT2A | |
| SCHEMBL7221272 | 0.75 | PPARG (0.43) | PPARGPPARAALDH1A1HTTPPARD | |
| SCHEMBL82055 | 0.75 | PPARG (0.53) | PPARGPPARAADORA3ELANEALDH1A1 | |
| SCHEMBL5322591 | 0.75 | PPARG (0.79) | PPARGPPARAPPARDPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268500-A | Aromatic urea carboxylated compound | MONTEFIORE MEDICAL CENTER (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0358724-A4 | COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION. | LALEZARI IRAJ (US) | 1990-06-05 | — | — | EP | disclosed |
| EP-0358724-A1 | COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION | LALEZARI, Iraj (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988010113-A1 | COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION | LALEZARI IRAJ (US) | 1988-12-29 | — | — | WO | disclosed |