SCHEMBL956221

SCHEMBL956221

Clc1nc(-c2ccccc2)cs1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.61
KDM4E B2RXH2 4/20 0.57
RAB9A P51151 4/20 0.57
KMT2A Q03164 3/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
MEN1 O00255 2/20 0.57
MAPT P10636 2/20 0.57
NPC1 O15118 2/20 0.57
LMNA P02545 1/20 0.57
NFKB1 P19838 1/20 0.57
NFKB2 Q00653 1/20 0.57
RELA Q04206 1/20 0.57
CYP3A4 P08684 1/20 0.57
AR P10275 2/20 0.53
GFER P55789 1/20 0.52
LOXL2 Q9Y4K0 1/20 0.50
SREBF2 Q12772 1/20 0.50
HSD17B10 Q99714 1/20 0.49
ALOX5 P09917 1/20 0.49
TAAR1 Q96RJ0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5239246 0.83 KDM4E (0.59) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL14755578 0.83 CYP19A1 (0.61) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL9955024 0.80 CYP19A1 (0.67) RAB9ASMN1; SMN2MAPTNPC1
SCHEMBL4907429 0.79 RAB9A (0.56) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL21283211 0.79 CYP19A1 (0.45) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL21283206 0.79 RAB9A (0.63) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL534232 0.79 CYP19A1 (0.41) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL9454811 0.77 ATP4A (0.56) ALDH1A1RAB9AKMT2ASMN1; SMN2MEN1
SCHEMBL9955922 0.77 KDM4E (0.68) ALDH1A1KDM4ERAB9AKMT2ASMN1; SMN2
SCHEMBL15351730 0.77 ALDH1A1 (0.68) ALDH1A1RAB9AKMT2ASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118647270-A Novel derivatives of non-coding amino acids and their use as herbicides 福提费斯特有限公司 2024-09-13 CN claimed
WO-2023131951-A1 NOVEL DERIVATIVES OF NON-CODED AMINO ACIDS AND THEIR USE AS HERBICIDES FORTEPHEST LTD. (IL) 2023-07-13 WO claimed
CN-105246336-B Use of tetramic acid derivatives as nematicides 先正达参股股份有限公司 2022-08-30 CN claimed
CN-118647270-A Novel derivatives of non-coding amino acids and their use as herbicides 福提费斯特有限公司 2024-09-13 CN disclosed
WO-2023131951-A1 NOVEL DERIVATIVES OF NON-CODED AMINO ACIDS AND THEIR USE AS HERBICIDES FORTEPHEST LTD. (IL) 2023-07-13 WO disclosed
CN-105246336-B Use of tetramic acid derivatives as nematicides 先正达参股股份有限公司 2022-08-30 CN disclosed
CN-109476629-B Urea and thiourea substituted bicyclic derivatives as pesticides 先正达参股股份有限公司 2022-04-15 CN disclosed
CN-110022682-B Pesticidally active heterocyclic derivatives with sulphur containing substituents 先正达参股股份有限公司 2022-03-01 CN disclosed
CN-109890208-B Fungicidal compositions 先正达参股股份有限公司 2021-10-22 CN disclosed
CN-113166080-A Pesticidally active cyclopropyl methyl amide derivatives 先正达农作物保护股份公司 2021-07-23 CN disclosed
CN-107207450-B Pesticidally active semicarbazone and thiosemicarbazone derivatives 先正达参股股份有限公司 2021-07-06 CN disclosed
US-5260445-A Hypoglycemic BEECHAM GROUP P.L.C. (GB) 1993-11-09 US disclosed
US-5232925-A Treating hypertension BEECHAM GROUP P.L.C. (GB) 1993-08-03 US disclosed
US-5194443-A Thiazolinediones, Hypoglycemic Agents, Antilipemic Agents BEECHAM GROUP P.L.C. (GB) 1993-03-16 US disclosed
US-5112841-A Anticonvulsants MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1992-05-12 US disclosed
EP-0446010-A1 Imidazole derivatives and antiepileptics comprising said imidazole derivatives as effective ingredients MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-09-11 EP disclosed
US-5002953-A Substituted Thiazolidinedione Derivatives BEECHAM GROUP P.L.C. (GB) 1991-03-26 US disclosed
EP-0306228-A1 Substituted thiazolidinedione derivatives BEECHAM GROUP PLC (GB) 1989-03-08 EP disclosed
US-4476128-A ANTIARTHRITIC AGENTS ANTIBODY INHIBITORS MITSUITOATSU CHEMICALS, INC. (JP) 1984-10-09 US disclosed
US-4112092-A CNS DISORDER, PARKINSON'S, CARDIOVASCULAR DISORDER SCIENCE UNION ET CIE (FR) 1978-09-05 US disclosed