Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563242 | 0.79 | IDO1 (0.41) | IDO1TDO2CES2CES1ALOX5 | |
| SCHEMBL9563280 | 0.79 | CES2 (0.42) | IDO1TDO2TSHRCES2CES1 | |
| SCHEMBL9563208 | 0.78 | MAPT (0.42) | TSHRCES2CES1KEAP1NPC1 | |
| SCHEMBL14033230 | 0.74 | SLC6A3 (0.42) | TSHRCNR2NPC1RAB9AKMT2A | |
| SCHEMBL9563316 | 0.74 | IDO1 (0.52) | IDO1TDO2TSHRALOX5RAB9A | |
| SCHEMBL7320913 | 0.73 | SLC6A3 (0.41) | TSHRKMT2AAHRMAPT | |
| SCHEMBL28618641 | 0.73 | CES2 (0.39) | IDO1TDO2TSHRCES2CES1 | |
| SCHEMBL791595 | 0.73 | IDO1 (0.44) | IDO1TDO2TSHRCES2CES1 | |
| SCHEMBL1560841 | 0.69 | — | — | |
| SCHEMBL1258559 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529365-A1 | Diarylmethoxypiperidine derivatives | Kaken Pharmaceutical Co., Ltd. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5190959-A | Antihistamines, antiallergens, treatment of ischemic heart disease | KAKEN PHARMACEUTICAL CO. LTD. (JP) | 1993-03-02 | — | — | US | disclosed |