SCHEMBL956342

SCHEMBL956342

Oc1cc(CCc2ccccc2Cl)nc2cc(Cc3ccccc3)nn12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FYN P06241 7/20 0.38
CXCR2 P25025 1/20 0.37
SLC16A3 O15427 1/20 0.36
SLC16A1 P53985 1/20 0.36
MCTS1 Q9ULC4 1/20 0.36
GRK5 P34947 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
PLAAT3 P53816 1/20 0.34
PLAAT5 Q96KN8 1/20 0.34
PLAAT2 Q9NWW9 1/20 0.34
PLAAT4 Q9UL19 1/20 0.34
HIF1A Q16665 1/20 0.34
BCL2 P10415 1/20 0.34
BCL2L1 Q07817 1/20 0.34
KCNMA1 Q12791 1/20 0.34
LMNA P02545 2/20 0.34
TP53 P04637 2/20 0.34
MAPT P10636 1/20 0.34
ALOX5 P09917 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30515690 1.00 FYN (0.38) FYNCXCR2SLC16A3SLC16A1MCTS1
SCHEMBL956084 0.86 CXCR2 (0.37) FYNCXCR2GRK5BCL2BCL2L1
SCHEMBL956296 0.83 CXCR2 (0.56) FYNCXCR2GRK5BCL2BCL2L1
SCHEMBL954341 0.76 ABCB1 (0.43) LMNATP53MAPTALDH1A1POLB
SCHEMBL957373 0.71 CXCR2 (0.55) CXCR2RXFP1LMNATP53MAPT
SCHEMBL3338299 0.70 CXCR2 (0.52) FYNCXCR2TP53
SCHEMBL7892524 0.68 MAPT (0.49) FYNLMNATP53MAPTALDH1A1
SCHEMBL954380 0.68 RXFP1 (0.47) CXCR2RXFP1LMNAMAPTALDH1A1
SCHEMBL7436883 0.65 MAPT (0.52) FYNLMNATP53MAPTALDH1A1
SCHEMBL957633 0.64 CXCR2 (0.52) CXCR2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-10660909-B2 Method for treating cancer using chemokine antagonists SYNTRIX BIOSYSTEMS INC. (US) 2020-05-26 US disclosed
WO-2019055509-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. (US) 2019-03-21 WO disclosed
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-23 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
WO-2017156270-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. (US) 2017-09-14 WO disclosed
US-20110009429-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 NOVARTIS AG (CH) 2011-01-13 US disclosed
EP-2257552-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 Novartis AG (CH) 2010-12-08 EP disclosed
WO-2009106539-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 NOVARTIS AG (CH) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS CXCR1, CXCR2, CXCR6 FYN 167/4885CXCR2 2/4885SLC16A3 1564/4885
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 FYN 801/4885CXCR2 2/4885SLC16A3 2764/4885
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders CXCR1, CXCR2, CXCR6 FYN 207/4885CXCR2 2/4885SLC16A3 1460/4885
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF CXCR1, CXCR2, FPR2 FYN 63/4885CXCR2 2/4885SLC16A3 1068/4885
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS CXCR1, CXCR2, CXCR5 FYN 1114/4885CXCR2 2/4885SLC16A3 865/4885
US-20110009429-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 CXCR2, CXCR1, CXCR3 FYN 337/4885CXCR2 1/4885SLC16A3 2529/4885
US-10660909-B2 Method for treating cancer using chemokine antagonists CXCR1, CXCR2, CXCR5 FYN 1114/4885CXCR2 2/4885SLC16A3 865/4885
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 FYN 801/4885CXCR2 2/4885SLC16A3 2764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.