SCHEMBL9564018

SCHEMBL9564018

CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(N)=O)c1I

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.63
SMN1; SMN2 Q16637 1/20 0.47
FLT3 P36888 2/20 0.40
KDR P35968 2/20 0.40
CSNK2A1 P68400 2/20 0.40
CDC7 O00311 1/20 0.40
PLK4 O00444 1/20 0.40
DYRK3 O43781 1/20 0.40
JAK2 O60674 1/20 0.40
ROCK2 O75116 1/20 0.40
PRKD3 O94806 1/20 0.40
MAP4K4 O95819 1/20 0.40
INSR P06213 1/20 0.40
CDK1 P06493 1/20 0.40
ROS1 P08922 1/20 0.40
PIM1 P11309 1/20 0.40
FGFR1 P11362 1/20 0.40
PRKACA P17612 1/20 0.40
FLT1 P17948 1/20 0.40
RPS6KB1 P23443 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9000039 0.96 LMNA (0.58) LMNASMN1; SMN2FLT3KDRCSNK2A1
SCHEMBL13360600 0.89 LMNA (0.62) LMNASMN1; SMN2FLT3KDRCSNK2A1
SCHEMBL9239081 0.86 LMNA (0.49) LMNASMN1; SMN2FLT3KDRCSNK2A1
SCHEMBL10875389 0.84 LMNA (0.68) LMNASMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL22680970 0.83 LMNA (0.68) LMNASMN1; SMN2KDM4EMEN1KMT2A
Diatrizoic Acid SCHEMBL8508 0.81 LMNA (0.67) LMNASMN1; SMN2KDM4EMEN1KMT2A
Diatrizoic Acid SCHEMBL7615048 0.81 LMNA (0.67) LMNASMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL9298885 0.81 LMNA (0.66) LMNASMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL11690984 0.81 LMNA (0.47) LMNASMN1; SMN2FLT3KDRCSNK2A1
SCHEMBL10031588 0.80 LMNA (0.59) LMNASMN1; SMN2KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5191119-A Process for producing non-ionic radiographic contrast media utilizing N-allylation COOK IMAGING CORP. (US) 1993-03-02 US disclosed
EP-0160036-A4 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA. BIOPHYSICA FOUNDATION (US) 1987-06-11 EP disclosed
US-4607123-A X-RAY CONTRAST AGENTS DR. FRANZ KOHLER CHEMIE GMBH (DE) 1986-08-19 US disclosed
US-4584401-A AMIDATION,ACYLATION,ALLYLATION AND OXIDATION OF BENZAMIDES TO FORMTRIS-GLYCOLS BIOPHYSICA FOUNDATION (US) 1986-04-22 US disclosed
EP-0177414-A1 Jodized triaminobenzene compounds, process for their preparation and their use in contrast products GUERBET S.A. (FR) 1986-04-09 EP disclosed
EP-0160036-A1 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA BIOPHYSICA FOUNDATION (US) 1985-11-06 EP disclosed
WO-1985001727-A1 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA BIOPHYSICA FOUNDATION (US) 1985-04-25 WO disclosed