SCHEMBL9564828

SCHEMBL9564828

COc1ccc(CCN2CCC(Cc3nc4ncnc(O)c4n3Cc3ccc(F)cc3)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 3/20 0.49
TACR2 P21452 2/20 0.49
TACR1 P25103 2/20 0.49
HTR1A P08908 4/20 0.49
SLC6A4 P31645 4/20 0.49
EED O75530 2/20 0.49
OPRM1 P35372 2/20 0.49
MEN1 O00255 1/20 0.49
MLNR O43193 1/20 0.49
CACNA1F O60840 1/20 0.49
USP2 O75604 1/20 0.49
ABCB11 O95342 1/20 0.49
EGFR P00533 1/20 0.49
LMNA P02545 1/20 0.49
HLA-A P04439 1/20 0.49
ERBB2 P04626 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
LCK P06239 1/20 0.49
FYN P06241 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564878 0.87 HRH1 (0.49) HRH1TACR2TACR1HTR1ASLC6A4
SCHEMBL9537962 0.82 HTR1A (0.57) HRH1TACR2TACR1HTR1ASLC6A4
Oxalic Acid SCHEMBL10546958 0.80 HRH1 (0.57) HRH1TACR2TACR1HTR1ASLC6A4
SCHEMBL9540175 0.78 KCNH2 (0.71) HRH1TACR2TACR1HTR1ASLC6A4
Bromide SCHEMBL9565007 0.78 KCNH2 (0.42) HRH1CYP1A2CYP3A4CHRM1HTR3A
Hydrochloric Acid SCHEMBL9537185 0.77 HTR1A (0.57) HRH1TACR2TACR1HTR1ASLC6A4
SCHEMBL9564863 0.77 NR4A2 (0.48) SSTR5KCNH2
SCHEMBL10547773 0.76 HTR1A (0.56) HRH1TACR2TACR1HTR1ASLC6A4
SCHEMBL10549990 0.75 HTR1A (0.53) HRH1TACR2TACR1HTR1ASLC6A4
SCHEMBL10548616 0.75 HTR1A (0.53) HRH1TACR2TACR1HTR1ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258380-A Antiallergens, antihistamines JANSSEN PHARMACEUTICA N.V. (BE) 1993-11-02 US disclosed
US-5041448-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-08-20 US disclosed
EP-0206415-A2 (4-Piperidinylmethyl and -hetero)purines JANSSEN PHARMACEUTICA N.V. (BE) 1986-12-30 EP disclosed