Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143545 | 0.79 | EGFR (0.44) | HDAC1EGFRKCNQ3KCNQ2KCNE1 | |
| SCHEMBL11237461 | 0.76 | KMT2A (0.55) | MEN1KMT2AKDM4ERAB9AALDH1A1 | |
| SCHEMBL9564884 | 0.73 | HDAC1 (0.47) | HDAC1MEN1KMT2AEGFRCYP11B1 | |
| SCHEMBL28188848 | 0.73 | MEN1 (0.77) | HDAC1MEN1KMT2AHDAC2SMN1; SMN2 | |
| SCHEMBL30785552 | 0.73 | CYP11B1 (0.57) | HDAC1MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL5648961 | 0.72 | CYP1A2 (0.54) | HDAC1MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL17984931 | 0.72 | CYP11B1 (0.56) | HDAC1MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL13812239 | 0.72 | LMNA (0.41) | HDAC1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL3705907 | 0.71 | MAOA (0.42) | HDAC1CYP11B1CYP11B2KCNQ3KCNQ2 | |
| SCHEMBL12968585 | 0.70 | CA1 (0.39) | HDAC1HDAC2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| EP-0206415-B1 | (4-PIPERIDINYLMETHYL AND -HETERO)PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-27 | — | — | EP | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| EP-0206415-A2 | (4-Piperidinylmethyl and -hetero)purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-30 | — | — | EP | disclosed |