Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565317 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2PRMT5WDR77CYP2A6PPARA | |
| SCHEMBL7436825 | 0.77 | ALK (0.56) | PRMT5WDR77CYP2A6BTKALK | |
| SCHEMBL9565364 | 0.72 | ALDH1A1 (0.50) | SMN1; SMN2CYP2A6PPARACYP2C19ALDH1A1 | |
| SCHEMBL1435798 | 0.71 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP2A6BTKALKPRKAA1 | |
| SCHEMBL20160862 | 0.70 | PPARA (0.51) | SMN1; SMN2CYP2A6PPARACYP2C19ALDH1A1 | |
| SCHEMBL11598851 | 0.70 | SMN1; SMN2 (0.87) | SMN1; SMN2CYP2A6BTKALDH1A1CYP1A2 | |
| SCHEMBL9565312 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2A6PPARACYP2C19ALDH1A1 | |
| SCHEMBL14736431 | 0.69 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP2A6PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL20487853 | 0.68 | MMP2 (0.52) | SMN1; SMN2CYP2C19ALDH1A1CYP1A2HPGD | |
| SCHEMBL831106 | 0.68 | SMN1; SMN2 (0.63) | SMN1; SMN2CYP2A6BTKMETAP2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543245-A1 | Renin inhibiting amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-26 | — | — | EP | disclosed |