Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11667029 | 0.72 | LMNA (0.33) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL4908709 | 0.72 | P2RX4 (0.31) | — | |
| SCHEMBL11882961 | 0.71 | LMNA (0.31) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3635590 | 0.70 | P2RX4 (0.39) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3760901 | 0.69 | CES2 (0.31) | — | |
| SCHEMBL7334709 | 0.69 | LMNA (0.47) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3521402 | 0.69 | ALDH1A1 (0.34) | — | |
| SCHEMBL11709141 | 0.68 | LMNA (0.31) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL8423726 | 0.68 | — | — | |
| SCHEMBL9527213 | 0.68 | LMNA (0.31) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523846-A2 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0272866-A1 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1988-06-29 | — | — | EP | disclosed |