Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565707 | 1.00 | MAPT (0.68) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL30020323 | 0.85 | MEN1 (0.53) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL9565687 | 0.84 | SIRT1 (0.54) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL9565688 | 0.84 | SIRT1 (0.54) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL9129353 | 0.81 | SIRT1 (0.57) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL9129357 | 0.81 | SIRT1 (0.57) | MAPTALDH1A1GAAHPGDSIRT1 | |
| SCHEMBL30020328 | 0.73 | KMT2A (0.66) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL12013725 | 0.73 | MEN1 (0.68) | MAPTALDH1A1GAAHPGDKMT2A | |
| SCHEMBL21601056 | 0.73 | SIRT1 (1.00) | SIRT1KMT2ASIRT2SIRT5 | |
| SCHEMBL13848494 | 0.73 | PSMB5 (0.67) | MAPTALDH1A1GAAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546661-A1 | Pyrimidine derivatives, method for preparation thereof and pharmaceutical composition having said derivatives as active elements | JAPAN ENERGY CORPORATION (JP) | 1993-06-16 | — | — | EP | disclosed |