Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565687 | 1.00 | SIRT1 (0.54) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9565730 | 0.88 | LRRK2 (0.46) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9565731 | 0.88 | LRRK2 (0.46) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9129357 | 0.84 | SIRT1 (0.57) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9565708 | 0.84 | MAPT (0.68) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9129353 | 0.84 | SIRT1 (0.57) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9565707 | 0.84 | MAPT (0.68) | SIRT1MAPTALDH1A1HPGDGAA | |
| SCHEMBL9565692 | 0.73 | MEN1 (0.48) | SIRT1MAPTALDH1A1GAAEEF2K | |
| SCHEMBL9565691 | 0.73 | MEN1 (0.48) | SIRT1MAPTALDH1A1GAAEEF2K | |
| SCHEMBL13943821 | 0.71 | MAPT (0.46) | MAPTALDH1A1GAARXFP1NOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546661-A1 | Pyrimidine derivatives, method for preparation thereof and pharmaceutical composition having said derivatives as active elements | JAPAN ENERGY CORPORATION (JP) | 1993-06-16 | — | — | EP | disclosed |