Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 12/20 | 0.62 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566811 | 0.94 | CXCR2 (0.57) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9515480 | 0.90 | CXCR2 (0.52) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566786 | 0.87 | CXCR2 (0.57) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566868 | 0.87 | CXCR2 (0.60) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566851 | 0.87 | P4HTM (0.58) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566760 | 0.86 | RAB9A (0.60) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566759 | 0.85 | CXCR2 (0.55) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566791 | 0.85 | P4HTM (0.62) | CXCR2CXCR1P4HTMNPC1RAB9A | |
| SCHEMBL9566897 | 0.85 | P4HTM (0.66) | P4HTMNPC1RAB9AALDH1A1 | |
| SCHEMBL12020864 | 0.84 | MEN1 (0.70) | CXCR2CXCR1P4HTMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |