Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | CCR7 | P32248 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946562 | 0.87 | KMO (0.51) | SYKKCNH2HDAC1KMO | |
| Hydrochloric Acid SCHEMBL934035 | 0.86 | KMO (0.50) | SYKKCNH2HDAC1KMO | |
| SCHEMBL934021 | 0.80 | SYK (0.41) | SYKKCNH2 | |
| SCHEMBL945743 | 0.80 | GSK3B (0.63) | GSK3BPIK3CBADORA3TSHRMC4R | |
| SCHEMBL28051973 | 0.79 | GSK3B (0.52) | GSK3BPIK3CBADORA3TSHRMC4R | |
| SCHEMBL944085 | 0.79 | CCNT1 (0.50) | GSK3BSYKCCR6 | |
| Hydrochloric Acid SCHEMBL9792812 | 0.76 | MKNK1 (0.52) | GSK3BPIK3CBADORA3TSHRMC4R | |
| SCHEMBL943650 | 0.75 | LRRK2 (0.51) | CCR7CCR6MKNK1MKNK2MYC | |
| SCHEMBL27772527 | 0.73 | MKNK1 (0.51) | GSK3BPIK3CBMKNK1MKNK2MYC | |
| SCHEMBL30595907 | 0.73 | OPRM1 (0.42) | GSK3BADORA3TSHRMC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |