SCHEMBL9568436

SCHEMBL9568436

CCOC(=O)c1c2n(c3c(OC)c(-c4ccc(N)cc4)c(F)cc3c1=O)CS2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 4/20 0.38
MAPT P10636 7/20 0.37
KMT2A Q03164 5/20 0.37
MEN1 O00255 4/20 0.37
ALOX15 P16050 2/20 0.37
USP2 O75604 1/20 0.37
GPR55 Q9Y2T6 1/20 0.36
GRM6 O15303 3/20 0.36
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
GAA P10253 2/20 0.35
LMNA P02545 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
HSD17B10 Q99714 1/20 0.35
HPGD P15428 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PDE4D Q08499 1/20 0.35
POLB P06746 2/20 0.34
XBP1 P17861 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9568351 0.91 PRKCZ (0.37) PRKCZMAPTKMT2AMEN1ALOX15
SCHEMBL9568340 0.91 MAPT (0.41) MAPTKMT2AMEN1GPR55GRM6
SCHEMBL9568379 0.90 PRKCZ (0.39) PRKCZMAPTKMT2AMEN1ALOX15
SCHEMBL9568438 0.90 MEN1 (0.38) PRKCZMAPTKMT2AMEN1ALOX15
SCHEMBL9568328 0.88 GSK3B (0.36)
SCHEMBL9568449 0.83 PRKCZ (0.38) PRKCZMAPTKMT2AMEN1ALOX15
SCHEMBL9568392 0.81 PRKCZ (0.35) PRKCZMAPTKMT2AMEN1GPR55
SCHEMBL9568352 0.81 MAPT (0.41) MAPTKMT2AMEN1GPR55GRM6
SCHEMBL9568333 0.80 TOP1 (0.39)
SCHEMBL9568349 0.80 MAPT (0.38) PRKCZMAPTKMT2AMEN1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0551518-A1 QUINOLINECARBOXYLIC ACID DERIVATIVE NIPPON SHINYAKU COMPANY, LIMITED (JP) 1993-07-21 EP disclosed