Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TOP2A | P11388 | 11/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569192 | 0.88 | TOP1 (0.37) | TOP1CYP3A4CYP2C9 | |
| SCHEMBL9509558 | 0.80 | TOP1 (0.52) | TOP1TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL9509708 | 0.74 | TOP1 (0.52) | TOP1TOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL9560362 | 0.72 | TOP1 (0.49) | TOP1TOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL9560538 | 0.71 | TOP1 (0.45) | TOP1TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL9569194 | 0.71 | TOP1 (0.51) | TOP1TOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL21729417 | 0.71 | TOP2A (0.69) | TOP2ATOP2BKDM4EKMT2AALDH1A1 | |
| SCHEMBL14754070 | 0.69 | TOP2A (0.58) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL10538537 | 0.68 | STAT3 (0.47) | TOP1PIM1KDM4EKMT2AALDH1A1 | |
| SCHEMBL17040509 | 0.68 | TOP2A (0.45) | CYP3A4CYP2C9TOP2ATOP2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563734-A1 | 9-fluoro-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acids and esters and their use as antiviral agents | BAYER AG (DE) | 1993-10-06 | — | — | EP | disclosed |