Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597058 | 0.83 | PDE10A (0.34) | PDE10AALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL27108411 | 0.79 | MAOA (0.39) | PDE10AALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL1272172 | 0.76 | RAB9A (0.33) | PDE10AALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL18782728 | 0.72 | HDAC8 (0.32) | — | |
| SCHEMBL2122234 | 0.68 | DYRK1A (0.42) | ALDH1A1KDM4EPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL3030493 | 0.68 | — | — | |
| SCHEMBL30170384 | 0.68 | PIK3CG (0.50) | ALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL29528777 | 0.68 | CCR1 (0.32) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9569919 | 0.67 | ERCC5 (0.34) | PDE10AALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL29528695 | 0.67 | PTGS1 (0.57) | KDM4EPOLBL3MBTL1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |