Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570042 | 0.94 | RAB9A (0.43) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL9597562 | 0.85 | AGTR1 (0.41) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL9570151 | 0.84 | AGTR1 (0.36) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL25383117 | 0.80 | AGTR1 (0.44) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL21369215 | 0.78 | AGTR1 (0.42) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL9570441 | 0.78 | KDM4E (0.31) | ALDH1A1KDM4EMAPT | |
| SCHEMBL11308568 | 0.75 | RAB9A (0.41) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL9598178 | 0.69 | AGTR1 (0.38) | AGTR1AGTR2RAB9ALMNAHTT | |
| SCHEMBL16812496 | 0.66 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9184676 | 0.65 | AGTR1 (0.35) | AGTR1AGTR2RAB9ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |