Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 6/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluparoxan SCHEMBL29401005 | 1.00 | SLC6A2 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Fluparoxan SCHEMBL7173629 | 1.00 | SLC6A2 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Fluparoxan SCHEMBL112164 | 1.00 | SLC6A2 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Fluparoxan SCHEMBL9482018 | 0.98 | HTR6 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Fluparoxan SCHEMBL122268 | 0.98 | HTR6 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Fluparoxan SCHEMBL9482026 | 0.98 | HTR6 (0.38) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL10375117 | 0.82 | BRD4 (0.36) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL10579193 | 0.81 | BRD4 (0.36) | SLC6A2SLC6A4SLC6A3HTR6HTR2C | |
| SCHEMBL10376272 | 0.81 | CHRNB2 (0.34) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| SCHEMBL10375154 | 0.81 | CHRNB2 (0.34) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532100-A1 | Benzodioxinopyrrole derivative as alpha 2-adrenoreceptor antagonist | GLAXO GROUP LIMITED (GB) | 1993-03-17 | — | — | EP | claimed |
| EP-0460912-A2 | Medicaments for the treatment of sexual disorder | GLAXO GROUP LIMITED (GB) | 1991-12-11 | — | — | EP | claimed |
| EP-0407016-A2 | Use of benzodioxinopyrrole derivatives in the manufacture of a medicament for the treatment of anxiety | GLAXO GROUP LIMITED (GB) | 1991-01-09 | — | — | EP | claimed |
| EP-0371793-A2 | Use of a benzodioxinopyrrole derivatives for the preparation of a medicament in the treatment of cerebral ischaemia | GLAXO GROUP LIMITED (GB) | 1990-06-06 | — | — | EP | claimed |
| WO-2013038200-A2 | NEURODEVELOPMENTAL DISORDERS | THE UNIVERSITY OF SUSSEX (GB) | 2013-03-21 | — | — | WO | disclosed |
| EP-0532100-A1 | Benzodioxinopyrrole derivative as alpha 2-adrenoreceptor antagonist | GLAXO GROUP LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| EP-0532100-A1 | Benzodioxinopyrrole derivative as alpha 2-adrenoreceptor antagonist | GLAXO GROUP LIMITED (GB) | 1993-03-17 | — | — | EP | disclosed |
| US-5032603-A | Tranquilizers | GLAXO GROUP LIMITED (GB) | 1991-07-16 | — | — | US | disclosed |
| EP-0221725-B1 | PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1990-08-08 | — | — | EP | disclosed |
| US-4837336-A | Process for preparing heterocyclic compounds | GLAXO GROUP LIMITED (GB) | 1989-06-06 | — | — | US | disclosed |
| US-4837336-A | Process for preparing heterocyclic compounds | GLAXO GROUP LIMITED (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0221725-A2 | Process for preparing heterocyclic compounds | GLAXO GROUP LIMITED (GB) | 1987-05-13 | — | — | EP | disclosed |