Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570295 | 0.87 | MAPT (0.64) | PKMMEN1KMT2AHTTMAPT | |
| SCHEMBL28678485 | 0.86 | PKM (0.62) | PKMMEN1KMT2AHTTCYP1A2 | |
| SCHEMBL4739771 | 0.86 | MEN1 (0.71) | PKMMEN1KMT2AHTTCYP1A2 | |
| SCHEMBL9570117 | 0.84 | GAA (0.64) | MEN1KMT2AHTTMAPTLMNA | |
| SCHEMBL9598289 | 0.83 | PKM (0.68) | PKMMEN1KMT2AHTTCYP1A2 | |
| SCHEMBL9569962 | 0.83 | TP53 (0.65) | HTTMAPTLMNAGAAALDH1A1 | |
| SCHEMBL9570000 | 0.83 | LMNA (0.59) | PKMMEN1KMT2AHTTMAPT | |
| SCHEMBL2900203 | 0.82 | MEN1 (0.66) | PKMMEN1KMT2AHTTCYP1A2 | |
| SCHEMBL9570313 | 0.82 | TP53 (0.63) | HTTMAPTLMNAGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL30281577 | 0.82 | PKM (0.70) | PKMMEN1KMT2AHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |