Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028474 | 0.81 | CETP (0.45) | CSNK1E | |
| SCHEMBL22922951 | 0.81 | KCNH2 (0.47) | KCNH2HTR2APTGESALOX5PPARG | |
| SCHEMBL25065427 | 0.81 | KCNH2 (0.47) | KCNH2HTR2APTGESALOX5PPARG | |
| SCHEMBL4749538 | 0.81 | KCNH2 (0.51) | KCNH2HTR2ASIGMAR1CSNK1E | |
| SCHEMBL2854089 | 0.81 | KCNH2 (0.51) | KCNH2HTR2ASIGMAR1CSNK1E | |
| SCHEMBL7062802 | 0.79 | SIGMAR1 (0.49) | KCNH2HTR2ASIGMAR1CSNK1E | |
| SCHEMBL7797335 | 0.78 | CSNK1E (0.44) | KCNH2HTR2APTGESALOX5PPARG | |
| SCHEMBL11785905 | 0.78 | SIGMAR1 (0.50) | KCNH2HTR2ASIGMAR1L3MBTL1 | |
| SCHEMBL19322733 | 0.77 | KCNH2 (0.59) | KCNH2HTR2ASIGMAR1TDP1L3MBTL1 | |
| SCHEMBL22268758 | 0.77 | KCNH2 (0.59) | KCNH2HTR2ASIGMAR1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243076-A | Adrenergic stimulant intermediates | GLAXO GROUP LTD. | 1993-09-07 | — | — | US | disclosed |
| US-5225445-A | Respiratory system disorders | GLAXO GROUP LTD. | 1993-07-06 | — | — | US | disclosed |
| US-5091422-A | Treating inflammatory or allergic skin disease, lowering gastric acidity | GLAXO GROUP LIMITED (GB) | 1992-02-25 | — | — | US | disclosed |
| US-4992474-A | Adrenergic stimulants | GLAXO GROUP LTD. (GB) | 1991-02-12 | — | — | US | disclosed |