Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9575167 | 0.79 | POLB (0.37) | POLB | |
| SCHEMBL1021383 | 0.77 | CFD (0.51) | SMN1; SMN2NPC1RAB9AHPGDTP53 | |
| SCHEMBL9575168 | 0.77 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9AKMT2ATSHR | |
| SCHEMBL9661038 | 0.75 | BCHE (0.47) | SMN1; SMN2RAB9AHPGDTP53KMT2A | |
| SCHEMBL9662600 | 0.74 | FABP3 (0.43) | NPC1RAB9ATP53KMT2ATSHR | |
| SCHEMBL3857991 | 0.73 | KMT2A (0.44) | SMN1; SMN2NPC1RAB9AHPGDTP53 | |
| SCHEMBL16415282 | 0.73 | KMT2A (0.55) | SMN1; SMN2NPC1RAB9AHPGDTP53 | |
| SCHEMBL9575390 | 0.73 | LDHA (0.41) | RAB9AKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL27614322 | 0.71 | KMT2A (0.52) | SMN1; SMN2NPC1RAB9AHPGDTP53 | |
| SCHEMBL16641129 | 0.71 | KDM4E (0.32) | RAB9ATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5266668-A | Substituted phenyl α-fluoroacrylates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-30 | — | — | US | disclosed |
| EP-0249867-B1 | SUBSTITUTED PHENYL ESTERS OF ALPHA-FLUOROACRYLIC ACID | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-02 | — | — | EP | disclosed |
| EP-0249867-A2 | Substituted phenyl esters of alpha-fluoroacrylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-12-23 | — | — | EP | disclosed |